Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 1 / 48 This SDS adheres to the standards and regulatory requirements of the United States and may not meet the regulatory requirements in other countries. SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Used Refrigerants and Refrigerant Blends Tradename/Synonym : USED REFRIGERANT R-22 USED REFRIGERANT R-134a USED REFRIGERANT R-125 USED REFRIGERANT R-32 USED REFRIGERANT R-124 USED REFRIGERANT R-12 USED REFRIGERANT R-13 USED REFRIGERANT R-14 USED REFRIGERANT R-11 USED REFRIGERANT R-23 USED REFRIGERANT R-113 USED REFRIGERANT R-114 USED REFRIGERANT R-116 USED REFRIGERANT R-123 USED REFRIGERANT R-401A (Suva ? MP39) USED REFRIGERANT R-401B (Suva ? MP66) USED REFRIGERANT R-401C (Suva ? MP-52) USED REFRIGERANT R-402A (Suva ? HP80) USED REFRIGERANT R-402B (Suva ? HP81) USED REFRIGERANT R-404A (Suva ? HP62) USED REFRIGERANT R-407A USED REFRIGERANT R-407C USED REFRIGERANT R-408A USED REFRIGERANT R-409A USED REFRIGERANT R-410A USED REFRIGERANT R-417A (ISCEON ? MO59) USED REFRIGERANT R-422A (ISCEON ? MO79) USED REFRIGERANT R-422D (ISCEON ? MO29) USED REFRIGERANT R-423A (ISCEON ? 39TC) USED REFRIGERANT R-437A (ISCEON ? MO49 Plus ? ) USED REFRIGERANT R-438A (ISCEON ? MO99 ? ) USED REFRIGERANT R-500 USED REFRIGERANT R-502 USED REFRIGERANT R-503 USED REFRIGERANT R-507 USED REFRIGERANT R-508B (Suva ? 95) USED REFRIGERANT R-236fa Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 2 / 48 Restrictions on use : Do not use product for anything outside of the above specified uses Manufacturer/Supplier : DuPont 1007 Market Street Wilmington, DE 19898 United States of America Product Information : +1-800-441-7515 (outside the U.S. +1-302-774-1000) Medical Emergency : 1-800-441-3637 (outside the U.S. 1-302-774-1139) Transport Emergency : CHEMTREC: +1-800-424-9300 (outside the U.S. +1-703-527-3887) Other information : The above components represent DuPont Refrigerant and Refrigerant Blends that are returned for reclamation. Any (and/or all) components may be contained in the material returned. The information is representative for any and all components. This specification for used refrigerant returned for reclamation is a maximum of 30% TOTAL lubricating oil content. Most used refrigerant contains significantly less. SECTION 2. HAZARDS IDENTIFICATION Product hazard category Gases under pressure Compressed gas Gases under pressure Liquefied gas Category 2A Label content Pictogram : Signal word : Warning Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 3 / 48 Hazardous warnings : Contains gas under pressure; may explode if heated. May cause respiratory irritation. May cause drowsiness or dizziness. Hazardous prevention measures : Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. Wash skin thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Avoid release to the environment. Wear protective gloves/ protective clothing/ eye protection/ face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/ physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/ physician. IF exposed or concerned: Get medical advice/ attention. IF exposed or if you feel unwell: Call a POISON CENTER or doctor/ physician. Specific treatment (see supplemental first aid instructions on this label). Rinse mouth. If skin irritation occurs: Get medical advice/ attention. If eye irritation persists: Get medical advice/ attention. Take off contaminated clothing and wash it before reuse. Store in a well-ventilated place. Keep container tightly closed. Store locked up. Protect from sunlight. Store in a well-ventilated place. Dispose of contents/ container to an approved waste disposal plant. Other hazards Misuse or intentional inhalation abuse may cause death without warning symptoms, due to cardiac effects., May cause cardiac arrhythmia., Vapours are heavier than air and can cause suffocation by reducing oxygen available for breathing., Rapid evaporation of the liquid may cause frostbite., Lubricants can cause skin irritation. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 4 / 48 SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Component CAS-No. Concentration Chlorodifluoromethane (HCFC-22) 75-45-6 0 - 100 % 1,1,1,2-Tetrafluoroethane (HFC-134a) 811-97-2 0 - 100 % Pentafluoroethane (HFC-125) 354-33-6 0 - 70 % Difluoromethane (HFC-32) 75-10-5 0 - 30 % 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124) 2837-89-0 0 - 100 % Trifluoromethane (HFC-23) 75-46-7 0 - 100 % 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) 306-83-2 0 - 100 % 1-Chloro-1,1-difluoroethane (HCFC-142b) 75-68-3 0 - 100 % 1,1,1,3,3,3-Hexafluoropropane (HFC-236fa) 690-39-1 0 - 100 % 1,1,1-Trifluoroethane (HFC-143a) 420-46-2 0 - 55 % 1,1,1,2,3,3,3-Heptafluoropropane (HFC-227ea) 431-89-0 0 - 50 % 1,1-Difluoroethane (HFC-152a) 75-37-6 0 - 30 % Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 5 / 48 Perfluoropropane (FC-218) 76-19-7 0 - 10 % Trichlorofluoromethane (CFC-11) 75-69-4 0 - 60 % Dichlorodifluoromethane (CFC-12) 75-71-8 0 - 60 % Chlorotrifluoromethane (CFC-13) 75-72-9 0 - 60 % Carbon Tetrafluoride(FC-14) 75-73-0 0 - 60 % 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) 76-13-1 0 - 60 % 1,2-Dichloro-1,1,2,2-tetrafluoroethane (CFC-114) 76-14-2 0 - 60 % Chloropentafluoroethane (CFC-115) 76-15-3 0 - 60 % Perfluoroethane (FC-116) 76-16-4 0 - 60 % Propane(HC-290) 74-98-6 0 - 6 % n-Butane (HC-600) 106-97-8 0 - 5 % Pentane(HC-601) 109-66-0 0 - 1 % Isobutane (HC-600a) 75-28-5 0 - 5 % 2-Methylbutane (HC-601a) 78-78-4 0 - 1 % Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 6 / 48 Alkylated Benzene 68648-86-2 0 - 30 % Polypropylene Glycol, monobutyl ether 9003-13-8 0 - 30 % Polyalkylene Glycol, monobutyl ether 9038-95-3 0 - 30 % Distillates (Petroleum), clay treated heavy naphthenic; base oil unspecified 64742-44-5 0 - 30 % Distillates (Petroleum), Solvent-Refined Heavy Paraffinic 64741-88-4 0 - 30 % Pentaerythritol esters of heptanoic and isononionic acids 118685-29-3 0 - 30 % Unspecified impurities 0 - 3 % SECTION 4. FIRST AID MEASURES General advice : When symptoms persist or in all cases of doubt seek medical advice. Inhalation : Remove from exposure, lie down. Move to fresh air. Keep patient warm and at rest. Artificial respiration and/or oxygen may be necessary. Consult a physician. Skin contact : Flush area with lukewarm water. Do not use hot water. If frostbite has occurred, call a physician. Eye contact : In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Consult a physician if necessary. Ingestion : Do not induce vomiting. If conscious, give 2 glasses of water. Get immediate medical attention. Never give anything by mouth to an unconscious person. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 7 / 48 Most important symptoms/effects, acute and delayed : Anaesthetic effects Light-headedness irregular heartbeat with a strange sensation in the chest, heart thumping, apprehension, feeling of fainting, dizziness or weakness Protection of first-aiders : If potential for exposure exists refer to Section 8 for specific personal protective equipment. Notes to physician : Because of possible disturbances of cardiac rhythm, catecholamine drugs, such as epinephrine, that may be used in situations of emergency life support should be used with special caution. SECTION 5. FIREFIGHTING MEASURES Suitable extinguishing media : As appropriate for combustibles in area. Extinguishant for other burning material in area is sufficient to stop burning. Unsuitable extinguishing media : No applicable data available. Specific hazards : Drums may rupture under fire conditions. Cylinders are equipped with pressure and temperature relief devices, but may still rupture under fire conditions. Decomposition may occur. Special protective equipment for firefighters : No applicable data available. Further information : Use water spray or fog to protect the fire fighters and to cool container. Self- contained breathing apparatus (SCBA) is required if containers rupture and contents are released under fire conditions. SECTION 6. ACCIDENTAL RELEASE MEASURES NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with clean-up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean-up. Safeguards (Personnel) : Ventilate spill area. Comply with Federal, State and Local regulations on reporting releases Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 8 / 48 Environmental precautions : Prevent material from entering sewers, waterways, or low areas. Spill Cleanup : Dike spill. Collect on absorbent material and transfer to steel drums for recovery/disposal. Accidental Release Measures : Self-contained breathing apparatus (SCBA) is required if a large release occurs. SECTION 7. HANDLING AND STORAGE Handling (Personnel) : Avoid breathing vapours or mist. Avoid contact with skin, eyes and clothing. Wash thoroughly after handling. Use sufficient ventilation to keep employee exposure below recommended limits. Handling (Physical Aspects) : No applicable data available. Dust explosion class : No applicable data available. Storage : Keep containers tightly closed and in an upright position. Store in a clean, dry place. Keep away from direct sunlight. Do not expose recovery cylinders to temperature above 52?C (125?F). Do not expose drums to direct heat or temperature above 46?C (115?F) to avoid pressurizing and possibly distorting the drums. Storage period : No applicable data available. Storage temperature : No applicable data available. SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Engineering controls : Normal ventilation for standard manufacturing procedures is generally adequate. Local exhaust should be used when large amounts are released. Mechanical ventilation should be used in low or enclosed places. Personal protective equipment Respiratory protection : Where there is potential for airborne exposures in excess of applicable limits, wear NIOSH approved respiratory protection. Hand protection : Additional protection: Impervious gloves Eye protection : Wear safety glasses with side shields. Additionally wear a face shield where the possibility exists for face contact due to splashing, spraying or airborne Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 9 / 48 contact with this material. Exposure Guidelines Exposure Limit Values Dichlorodifluoromethane (CFC-12) Permissible exposure limit: (OSHA) 1,000 ppm 4,950 mg/m3 8 hr. TWA TLV (ACGIH) 1,000 ppm TWA Trichlorofluoromethane (CFC-11) Permissible exposure limit: (OSHA) 1,000 ppm 5,600 mg/m3 8 hr. TWA TLV (ACGIH) 1,000 ppm TLV-C 1,1,1,2-Tetrafluoroethane (HFC-134a) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA 1-Chloro-1,1-difluoroethane (HCFC-142b) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) AEL * (DUPONT) 50 ppm 8 & 12 hr. TWA Chlorotrifluoromethane (CFC-13) No applicable data available. Chlorodifluoromethane (HCFC-22) TLV (ACGIH) 1,000 ppm TWA 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA Trichlorotrifluoroethane (CFC-113A) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 10 / 48 1,2-Dichloro-1,1,2,2-tetrafluoroethane (CFC-114) Permissible exposure limit: (OSHA) 1,000 ppm 7,000 mg/m3 8 hr. TWA TLV (ACGIH) 1,000 ppm TWA Pentafluoroethane (HFC-125) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA 1,1,1-Trifluoroethane (HFC-143a) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA 1,1,1,2,3,3,3-Heptafluoropropane (HFC-227ea) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA 1,1-Difluoroethane (HFC-152a) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA Difluoromethane (HFC-32) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA Perfluoropropane (FC-218) AEL * (DUPONT) 1,000 ppm 8 & 12 hr. TWA Propane(HC-290) Permissible exposure limit: (OSHA) 1,000 ppm 1,800 mg/m3 8 hr. TWA Isobutane (HC-600a) TLV (ACGIH) 1,000 ppm STEL TLV (ACGIH) 1,000 ppm STEL Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 11 / 48 n-Butane (HC-600) TLV (ACGIH) 1,000 ppm STEL Pentane(HC-601) Permissible exposure limit: (OSHA) 1,000 ppm 2,950 mg/m3 8 hr. TWA TLV (ACGIH) 1,000 ppm TWA AEL * (DUPONT) 600 ppm 8 & 12 hr. TWA 2-Methylbutane (HC-601a) TLV (ACGIH) 1,000 ppm TWA Carbon Tetrafluoride(FC-14) No applicable data available. * AEL is DuPont's Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence. SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Physical state : gaseous Form : liquid, Compressed gas, Liquefied gas Color : clear, colourless, light yellow Odor : slight, ether-like Odor threshold : No applicable data available. pH : No applicable data available. Melting point/range : No applicable data available. Boiling point/boiling range : No applicable data available. Flash point : Pure refrigerants will not burn. However, the lubricating oil contaminants will burn and they may be at a high enough concentration that the mixture will Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 12 / 48 burn. Evaporation rate : No applicable data available. Flammability (solid, gas) : No applicable data available. Upper explosion limit : No applicable data available. Lower explosion limit : No applicable data available. Vapour Pressure : No applicable data available. Vapour density : No applicable data available. Specific gravity (Relative density) : No applicable data available. Water solubility : No applicable data available. Solubility(ies) : No applicable data available. Partition coefficient: n- octanol/water : No applicable data available. Auto-ignition temperature : No applicable data available. Decomposition temperature : No applicable data available. Viscosity, kinematic : No applicable data available. Viscosity, dynamic : No applicable data available. SECTION 10. STABILITY AND REACTIVITY Reactivity : No applicable data available. Chemical stability : Stable Possibility of hazardous reactions : Polymerization will not occur. Conditions to avoid : Avoid open flames and high temperatures. Incompatible materials : Alkali metals Alkaline earth metals, Powdered metals, Powdered metal salts, The Refined Mineral Oils are incompatible with strong oxidizers. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 13 / 48 Hazardous decomposition products : Decomposition products are hazardous., This material can be decomposed by high temperatures (open flames, glowing metal surfaces, etc.) forming hydrochloric and hydrofluoric acids, and possibly carbonyl halides., Refined Mineral Oils, if present, can produce carbon monoxide and carbon dioxide upon combustion. SECTION 11. TOXICOLOGICAL INFORMATION Chlorodifluoromethane (HCFC-22) Inhalation 4 h LC50 : > 150000 ppm , Mouse Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 50000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 25000 ppm , Dog Cardiac sensitization Skin irritation : Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Not expected to cause sensitization based on expert review of the properties of the substance. Repeated dose toxicity : Inhalation Mouse - gas No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is not carcinogenic. Mutagenicity : Animal testing did not show any mutagenic effects. Experiments showed mutagenic effects in cultured bacterial cells. Reproductive toxicity : No toxicity to reproduction Teratogenicity : Animal testing showed effects on embryo-fetal development at levels Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 14 / 48 equal to or above those causing maternal toxicity. Further information : Cardiac sensitisation threshold limit : 175000 mg/m3 1,1,1,2-Tetrafluoroethane (HFC-134a) Inhalation 4 h LC50 : > 567000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 40000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 80000 ppm , Dog Cardiac sensitization Skin irritation : No skin irritation, Rabbit Eye irritation : No eye irritation, Rabbit Skin sensitization : Does not cause skin sensitisation., Guinea pig Does not cause respiratory sensitisation., Rat Repeated dose toxicity : Inhalation Rat - gas NOAEL: 50000, No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is not carcinogenic. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction No effects on or via lactation Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 334000 mg/m3 Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 15 / 48 Pentafluoroethane (HFC-125) Inhalation 4 h LC50 : > 800000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 75000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 100000 ppm , Dog Cardiac sensitization Skin sensitization : Does not cause respiratory sensitisation., human Repeated dose toxicity : Inhalation Rat - gas No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is not carcinogenic. Mutagenicity : Animal testing did not show any mutagenic effects. Evidence suggests this substance does not cause genetic damage in cultured mammalian cells. Did not cause genetic damage in cultured bacterial cells. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 490000 mg/m3 Difluoromethane (HFC-32) Inhalation 4 h LC50 : > 520000 ppm , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : > 350000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 350000 ppm , Dog Cardiac sensitization Skin irritation : No skin irritation, Not tested on animals Not expected to cause skin irritation based on expert review of the Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 16 / 48 properties of the substance. Eye irritation : No eye irritation, Not tested on animals Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Does not cause skin sensitisation., Not tested on animals Not expected to cause sensitization based on expert review of the properties of the substance. There are no reports of human respiratory sensitization. Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Information given is based on data obtained from similar substances. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : > 735000 mg/m3 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124) Inhalation 4 h LC50 : > 230000 ppm , Rat Anaesthetic effects Central nervous system effects Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 25000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 10000 ppm , Dog Cardiac sensitization Skin irritation : Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : Not expected to cause eye irritation based on expert review of the Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 17 / 48 properties of the substance. Skin sensitization : Not expected to cause sensitization based on expert review of the properties of the substance. Does not cause respiratory sensitisation., There are no reports of human respiratory sensitization. Repeated dose toxicity : Inhalation multiple species - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 140000 mg/m3 Trifluoromethane (HFC-23) Inhalation 4 h LC50 : > 663000 ppm , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : > 500000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 500000 ppm , Dog Cardiac sensitization Repeated dose toxicity : Inhalation Rat - NOAEL: 28.634 mg/l No toxicologically significant effects were found. Mutagenicity : Animal testing did not show any mutagenic effects. Evidence suggests this substance does not cause genetic damage in animals. Reproductive toxicity : No toxicity to reproduction Evidence suggests the substance is not a reproductive toxin in Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 18 / 48 animals. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : > 172414 mg/m3 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) Inhalation : Target Organs: Central nervous systemCentral nervous system effects Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 20000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 10000 ppm , Dog Cardiac sensitization Dermal LD50 : > 2,000 mg/kg , Rabbit Dermal LD50 : > 2,000 mg/kg , Rat Oral LD50 : 9,000 mg/kg , Rat Respiratory effects Abnormal posture Skin irritation : No skin irritation, Rabbit Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : No eye irritation, Rabbit Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Does not cause skin sensitisation., Guinea pig Did not cause sensitisation on laboratory animals. Not expected to cause sensitization based on expert review of the properties of the substance. Does not cause respiratory sensitisation., multiple species Repeated dose toxicity : Inhalation Rat - vapour No toxicological effects warranting significant target organ toxicity Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 19 / 48 classification were seen below the recommended guidance values for classification. Carcinogenicity : Not classifiable as a human carcinogen. The observed tumors do not appear to be relevant for men. Mutagenicity : Animal testing did not show any mutagenic effects. Did not cause genetic damage in cultured bacterial cells. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. No effects on or via lactation Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 124000 mg/m3 1-Chloro-1,1-difluoroethane (HCFC-142b) Inhalation 4 h LC50 : > 400000 ppm , Rat Target Organs: Central nervous system narcosis Lethargy Laboured breathing lung effects Kidney effects Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 50000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 25000 ppm , Dog Cardiac sensitization Repeated dose toxicity : Inhalation multiple species - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Mutagenicity : Animal testing did not show any mutagenic effects. Genetic damage in cultured mammalian cells was observed in some laboratory tests but not in others. Genetic damage in cultured bacterial cells was observed in some laboratory tests but not in others. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 20 / 48 Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 205000 mg/m3 1,1,1,3,3,3-Hexafluoropropane (HFC-236fa) Inhalation 4 h LC50 : > 457000 ppm , Rat Inhalation 4 h LC50 : > 189000 ppm , Rat Target Organs: Central nervous system Narcotic effects Central nervous system effects Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 150000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 100000 ppm , Dog Cardiac sensitization Skin irritation : No skin irritation, Not tested on animals Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : No eye irritation, Not tested on animals Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Does not cause skin sensitisation., Not tested on animals Not expected to cause sensitization based on expert review of the properties of the substance. There are no reports of human respiratory sensitization. Repeated dose toxicity : Inhalation Rat - gas No toxicologically significant effects were found. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Reproductive toxicity : No toxicity to reproduction Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 21 / 48 Evidence suggests the substance is not a reproductive toxin in animals. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 932751 mg/m3 1,1,1-Trifluoroethane (HFC-143a) Inhalation 4 h LC50 : > 591000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 250000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 300000 ppm , Dog Cardiac sensitization Skin sensitization : Does not cause respiratory sensitisation., human Repeated dose toxicity : Inhalation Rat - gas NOAEL: > 40000, Method: OECD Test Guideline 413 No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction No effects on or via lactation Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 862068.97 mg/m3 1,1,1,2,3,3,3-Heptafluoropropane (HFC-227ea) Inhalation 4 h LC50 : > 788696 ppm , Rat Central nervous system effects Respiratory effects Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 22 / 48 Inhalation No Observed Adverse Effect Concentration : 90000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 105000 ppm , Dog Cardiac sensitization Skin sensitization : Does not cause respiratory sensitisation., human Repeated dose toxicity : Inhalation Rat - gas NOAEL: 731.69 mg/l No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 730190 mg/m3 1,1-Difluoroethane (HFC-152a) Inhalation 4 h LC50 : > 437500 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 50000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 150000 ppm , Dog Cardiac sensitization Skin sensitization : Does not cause respiratory sensitisation., Rat Repeated dose toxicity : Inhalation Rat - Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 23 / 48 NOAEL: 67.485 mg/l No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Animal testing did not show any mutagenic effects. Did not cause genetic damage in cultured bacterial cells. Tests on mammalian cell cultures showed mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 405000 mg/m3 Perfluoropropane (FC-218) Inhalation 4 h LC50 : 400000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 300000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 400000 ppm , Dog Cardiac sensitization Mutagenicity : Animal testing did not show any mutagenic effects. Did not cause genetic damage in cultured bacterial cells. Further information : Cardiac sensitisation threshold limit : 3080000 mg/m3 Trichlorofluoromethane (CFC-11) Inhalation 4 h LC50 : > 65680 ppm , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : Dog Cardiac sensitization Inhalation No observed adverse effect level : Dog Cardiac sensitization Dermal LD50 : > 9,300 mg/kg , Rabbit Oral LD50 : > 11,000 mg/kg , Rat Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 24 / 48 Repeated dose toxicity : Ingestion multiple species - 90 d NOAEL: > 450 mg/kg No toxicologically significant effects were found. Inhalation multiple species - 28 d No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is not carcinogenic. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Dichlorodifluoromethane (CFC-12) Inhalation 4 h LC50 : 1200000 ppm , Rat Central nervous system effects Inhalation No observed adverse effect level : 25000 ppm , multiple species Cardiac sensitization Dermal : no data available Oral LD50 : > 1,000 mg/kg , Rat Skin irritation : No skin irritation, Guinea pig Eye irritation : slight irritation, Rabbit Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found. Oral multiple species - No toxicologically significant effects were found. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 25 / 48 Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Teratogenicity : Animal testing showed no developmental toxicity. Chlorotrifluoromethane (CFC-13) Inhalation 4 h LC50 : > 425000 ppm , Rat narcosis Inhalation : Dog Cardiac sensitization Dermal : Not applicable Oral : Not applicable Skin irritation : No skin irritation, Not tested on animals Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : No eye irritation, Not tested on animals Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Not tested on animals Not expected to cause sensitization based on expert review of the properties of the substance. Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found. Mutagenicity : Did not cause genetic damage in cultured bacterial cells. Further information : Cardiac sensitisation threshold limit : 3419222 mg/m3 Carbon Tetrafluoride(FC-14) Inhalation : Target Organs: Central nervous systemCentral nervous system Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 26 / 48 depression 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) Inhalation 4 h : 521 mg/l , Rat Target Organs: Central nervous system Central nervous system effects Breathing difficulties Tremors Hyperactivity Convulsions altered hematology Inhalation 4 h LC50 : 404 mg/l , Rat Target Organs: Central nervous system Central nervous system effects Liver effects Kidney effects lung effects Altered respiratory rate Anaesthetic effects Incoordination Convulsions Inhalation : 5000 ppm , Dog Cardiac sensitization Dermal LD50 : > 11,000 mg/kg , Rabbit Oral LD50 : 43,000 mg/kg , Rat Liver effects Kidney effects lung effects Gastrointestinal effects Lethargy Altered respiratory rate Fluid retention in lungs (pulmonary oedema) Skin irritation : slight irritation, Rabbit Eye irritation : slight irritation, Rabbit Skin sensitization : Did not cause sensitisation on laboratory animals., Guinea pig Repeated dose toxicity : Dermal Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 27 / 48 Rabbit - Skin irritation, Kidney damage, Liver damage Oral Rabbit - Increased mortality or reduced survival Inhalation Rat - Weight loss, altered blood chemistry Inhalation Rat - No toxicologically significant effects were found. Inhalation Rat - lung effects Inhalation human - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on mammalian cell cultures showed mutagenic effects. Did not cause genetic damage in cultured bacterial cells. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 38300 mg/m3 1,2-Dichloro-1,1,2,2-tetrafluoroethane (CFC-114) Inhalation 4 h ALC - : > 424000 ppm , Rat Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 28 / 48 Approximate Lethal Concentration Target Organs: Central nervous system Central nervous system depression Inhalation : Cardiac sensitization Repeated dose toxicity : Inhalation multiple species - No toxicologically significant effects were found. Oral multiple species - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Animal testing did not show any mutagenic effects. Did not cause genetic damage in cultured bacterial cells. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 175000 mg/m3 Chloropentafluoroethane (CFC-115) Inhalation 4 h LC50 : > 800000 ppm , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 150000 ppm , Dog Cardiac sensitization Repeated dose toxicity : Inhalation multiple species - gas No toxicologically significant effects were found. Mutagenicity : Did not cause genetic damage in cultured bacterial cells. Further information : Cardiac sensitisation threshold limit : 947669 mg/m3 Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 29 / 48 Further information : Cardiac sensitisation threshold limit : 1263803 mg/m3 Perfluoroethane (FC-116) Inhalation 4 h LC50 : > 500000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 200000 ppm , Dog Cardiac sensitization Repeated dose toxicity : Inhalation Rat - Method: OECD Test Guideline 412 No toxicologically significant effects were found. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 1129943.5 mg/m3 Propane(HC-290) Inhalation 4 h LC50 : > 200000 ppm , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 100000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 50000 ppm , Dog Cardiac sensitization Dermal : Not applicable Oral : Not applicable Skin irritation : Not applicable Eye irritation : Not applicable Skin sensitization : Not applicable Repeated dose toxicity : Inhalation Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 30 / 48 Rat - gas No toxicologically significant effects were found. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 180369 mg/m3 n-Butane (HC-600) Inhalation 4 h LC50 : 277018 ppm , Rat Target Organs: Respiratory Tract, Central nervous system Irritating to respiratory system. Central nervous system depression narcosis Dermal : Not applicable Oral : Not applicable Skin irritation : No skin irritation, Not tested on animals Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : No eye irritation, Not tested on animals Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Not tested on animals There are no reports of human skin sensitization. Not expected to cause sensitization based on expert review of the properties of the substance. Repeated dose toxicity : Inhalation multiple species - No toxicologically significant effects were found. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 31 / 48 Mutagenicity : Animal testing did not show any mutagenic effects. Pentane(HC-601) Inhalation 4 h LC50 : 70000 ppm , Mouse Irritating to respiratory system. narcosis Inhalation 4 h LC50 : > 20 mg/l , Rat Dermal : Not applicable Oral LD50 : > 2,000 mg/kg , Rat Not applicable Skin irritation : slight irritation, Rabbit Eye irritation : No eye irritation, Rabbit Skin sensitization : Animal test did not cause sensitization by skin contact., Guinea pig Repeated dose toxicity : Oral Rat - No toxicologically significant effects were found. Inhalation Rat - No toxicologically significant effects were found. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Isobutane (HC-600a) Inhalation 4 h LC50 : 276808 ppm , Rat The toxicological data has been taken from products of similar composition. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 32 / 48 Inhalation 4 h LC50 : > 31 mg/l , Rat Inhalation Low Observed Adverse Effect Concentration (LOAEC) : 50000 ppm , Dog Cardiac sensitization Inhalation No Observed Adverse Effect Concentration : 25000 ppm , Dog Cardiac sensitization Dermal : Not applicable Oral : Not applicable Skin irritation : No skin irritation, Not tested on animals Not expected to cause skin irritation based on expert review of the properties of the substance. Eye irritation : No eye irritation, Not tested on animals Not expected to cause eye irritation based on expert review of the properties of the substance. Skin sensitization : Not tested on animals Not expected to cause sensitization based on expert review of the properties of the substance. Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Further information : Cardiac sensitisation threshold limit : 118.9 mg/m3 2-Methylbutane (HC-601a) Inhalation 4 h LC50 : 1,281.9 mg/l , Rat Target Organs: Central nervous system Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 33 / 48 Central nervous system depression narcosis Inhalation 4 h LC50 : 70000 ppm , Rat Oral LD50 : > 2,000 mg/kg , Rat Skin irritation : slight irritation, human Eye irritation : No eye irritation, Rabbit Skin sensitization : Did not cause sensitisation on laboratory animals., Guinea pig Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Alkylated Benzene Dermal LD50 : > 2,000 mg/kg , Rat Oral LD50 : > 5,000 mg/kg , Rat Skin irritation : No skin irritation, Rabbit slight irritation Eye irritation : No eye irritation, Rabbit slight irritation Skin sensitization : Patch test on human volunteers did not demonstrate sensitisation properties., human Repeated dose toxicity : Inhalation Rat - Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 34 / 48 No toxicologically significant effects were found. Dermal Mouse - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed effects on embryo-fetal development at levels equal to or above those causing maternal toxicity. Polypropylene Glycol, monobutyl ether Inhalation 4 h LC50 : > 100 mg/l , Rat Dermal LD50 : > 2,000 mg/kg , Rat Oral LD50 : 300 - 2,000 mg/kg , Rat Skin irritation : Skin irritation, Rabbit Eye irritation : Eye irritation, Rabbit Skin sensitization : Does not cause skin sensitisation., human Patch test on human volunteers did not demonstrate sensitisation properties. Repeated dose toxicity : Oral Rat - No toxicologically significant effects were found. Inhalation Rat - No toxicologically significant effects were found. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 35 / 48 Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Evidence suggests this substance does not cause genetic damage in animals. Reproductive toxicity : No toxicity to reproduction No effects on or via lactation Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed no developmental toxicity. Polyalkylene Glycol, monobutyl ether Dermal LD50 : > 2,000 mg/kg , Rabbit Oral LD50 : > 5,000 mg/kg , Rat Skin irritation : No skin irritation, Rabbit slight irritation Eye irritation : No eye irritation, Rabbit Skin sensitization : Does not cause skin sensitisation., human Patch test on human volunteers did not demonstrate sensitisation properties. Repeated dose toxicity : Oral Rat - No adverse effect has been observed in chronic toxicity tests. Inhalation Rat - lung effects, Reversible Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Distillates (Petroleum), clay treated heavy naphthenic; base oil unspecified Inhalation 4 h LC50 : > 5.53 mg/l , Rat Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 36 / 48 Dermal LD50 : > 2,000 mg/kg , Rat Oral LD50 : > 5,000 mg/kg , Rat Skin irritation : No skin irritation, Rabbit slight irritation Eye irritation : No eye irritation, Rabbit slight irritation Skin sensitization : Does not cause skin sensitisation., animals (unspecified species) Repeated dose toxicity : Dermal Rat - No toxicologically significant effects were found. Inhalation Rat - No toxicologically significant effects were found. Carcinogenicity : Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Evidence suggests this substance does not cause genetic damage in animals. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Teratogenicity : Animal testing showed effects on embryo-fetal development at levels equal to or above those causing maternal toxicity. Distillates (Petroleum), Solvent-Refined Heavy Paraffinic Inhalation 4 h LC50 : > 5.0 mg/l , Rat The toxicological data has been taken from products of similar composition. Dermal LD50 : > 5,000 mg/kg , Rabbit The toxicological data has been taken from products of similar Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 37 / 48 composition. Oral LD50 : > 5,000 mg/kg , Rat The toxicological data has been taken from products of similar composition. Skin irritation : No skin irritation, Rabbit The toxicological data has been taken from products of similar composition. Eye irritation : No eye irritation, Rabbit The toxicological data has been taken from products of similar composition. Skin sensitization : Did not cause sensitisation on laboratory animals., Guinea pig The toxicological data has been taken from products of similar composition. Does not cause respiratory sensitisation., Not tested on animals The toxicological data has been taken from products of similar composition. Repeated dose toxicity : Inhalation Rat - No toxicologically significant effects were found., The toxicological data has been taken from products of similar composition. Dermal Rabbit - No toxicologically significant effects were found., The toxicological data has been taken from products of similar composition. Carcinogenicity : Not classifiable as a human carcinogen. Information given is based on data obtained from similar substances. Mutagenicity : Tests on bacterial or mammalian cell cultures did not show mutagenic effects. Animal testing did not show any mutagenic effects. Information given is based on data obtained from similar substances. Reproductive toxicity : No toxicity to reproduction Animal testing showed no reproductive toxicity. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 38 / 48 The toxicological data has been taken from products of similar composition. Teratogenicity : Animal testing showed effects on embryo-fetal development at levels equal to or above those causing maternal toxicity. Information given is based on data obtained from similar substances. Carcinogenicity The carcinogenicity classifications for this product and/or its ingredients have been determined according to HazCom 2012, Appendix A.6. The classifications may differ from those listed in the National Toxicology Program (NTP) Report on Carcinogens (latest edition) or those found to be a potential carcinogen in the International Agency for Research on Cancer (IARC) Monographs (latest edition). None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, or OSHA, as a carcinogen. SECTION 12. ECOLOGICAL INFORMATION Aquatic Toxicity Chlorodifluoromethane (HCFC-22) 96 h LC50 : Zebra fish 777 mg/l 96 h EC50 : Algae 250 mg/l 48 h EC50 : Daphnia magna (Water flea) 433 mg/l 1,1,1,2-Tetrafluoroethane (HFC-134a) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 450 mg/l 96 h ErC50 : Algae 142 mg/l Information given is based on data obtained from similar substances. 72 h NOEC : Pseudokirchneriella subcapitata (green algae) 13.2 mg/l Information given is based on data obtained from similar substances. 48 h EC50 : Daphnia magna (Water flea) 980 mg/l Pentafluoroethane (HFC-125) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 450 mg/l Information given is based on data obtained from similar substances. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 39 / 48 96 h ErC50 : Algae 142 mg/l Information given is based on data obtained from similar substances. 72 h NOEC : Pseudokirchneriella subcapitata (green algae) 13.2 mg/l Information given is based on data obtained from similar substances. 48 h EC50 : Daphnia magna (Water flea) 980 mg/l Information given is based on data obtained from similar substances. Difluoromethane (HFC-32) 96 h LC50 : Fish 1,507 mg/l 96 h EC50 : Algae 142 mg/l 48 h EC50 : Daphnia (water flea) 652 mg/l 30 d : NOEC Fish (unspecified species) 65.8 mg/l Trifluoromethane (HFC-23) 96 h LC50 : Pimephales promelas (fathead minnow) 633.26 mg/l 96 h EC50 : Algae 154.54 mg/l 48 h EC50 : Daphnia magna (Water flea) 323.05 mg/l 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 55.5 mg/l 96 h ErC50 : Pseudokirchneriella subcapitata (green algae) 96.6 mg/l 96 h EbC50 : Pseudokirchneriella subcapitata (green algae) 67.8 mg/l 48 h EC50 : Daphnia magna (Water flea) 17.3 mg/l 1-Chloro-1,1-difluoroethane (HCFC-142b) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 36 mg/l 48 h EC50 : Daphnia magna (Water flea) > 190 mg/l 1,1,1,3,3,3-Hexafluoropropane (HFC-236fa) 96 h LC50 : Zebra fish 292 mg/l 96 h ErC50 : Pseudokirchneriella subcapitata (microalgae) > 186 mg/l Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 40 / 48 48 h EC50 : Daphnia magna (Water flea) 299 mg/l 1,1,1-Trifluoroethane (HFC-143a) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) > 40 mg/l OECD Test Guideline 203 96 h ErC50 : Pseudokirchneriella subcapitata (green algae) > 44 mg/l OECD Test Guideline 201 48 h EC50 : Daphnia magna (Water flea) 300 mg/l OECD Test Guideline 202 1,1,1,2,3,3,3-Heptafluoropropane (HFC-227ea) 96 h LC50 : Danio rerio (zebra fish) > 200 mg/l OECD Test Guideline 203 Information given is based on data obtained from similar substances. 72 h ErC50 : Pseudokirchneriella subcapitata (green algae) > 114 mg/l OECD Test Guideline 201 Information given is based on data obtained from similar substances. 72 h NOEC : Pseudokirchneriella subcapitata (green algae) 13.2 mg/l OECD Test Guideline 201 Information given is based on data obtained from similar substances. 48 h EC50 : Daphnia magna (Water flea) > 200 mg/l OECD Test Guideline 202 Information given is based on data obtained from similar substances. 1,1-Difluoroethane (HFC-152a) 96 h LC50 : Fish 295.78 mg/l 96 h EC50 : Algae 47.76 mg/l 48 h EC50 : Daphnia (water flea) 146.7 mg/l Perfluoropropane (FC-218) : This product has no known ecotoxicological effects. : This product has no known ecotoxicological effects. : This product has no known ecotoxicological effects. : NOEC Fish (unspecified species) Due to its physical properties, there is no potential for adverse effects. : NOEC Daphnia (water flea) Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 41 / 48 Due to its physical properties, there is no potential for adverse effects. Trichlorofluoromethane (CFC-11) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 190 mg/l 48 h EC50 : Daphnia magna (Water flea) 130 mg/l Dichlorodifluoromethane (CFC-12) 48 h LC50 : Oryzias latipes (Orange-red killifish) 67 mg/l 48 h EC50 : Daphnia magna (Water flea) 95 mg/l 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 7.4 mg/l 96 h LC50 : Pimephales promelas (fathead minnow) > 1,000 mg/l 96 h EC50 : Algae 8.75 mg/l 48 h EC50 : Daphnia magna (Water flea) 71 mg/l 1,2-Dichloro-1,1,2,2-tetrafluoroethane (CFC-114) 96 h LC50 : Fish 21.5 mg/l 96 h EC50 : Algae 16 mg/l 48 h EC50 : Daphnia (water flea) 24.4 mg/l Chloropentafluoroethane (CFC-115) : No acute toxicity effects at concentrations up to the limit of aqueous solubility : No acute toxicity effects at concentrations up to the limit of aqueous solubility Perfluoroethane (FC-116) 96 h LC50 : Pimephales promelas (fathead minnow) 82.3 mg/l 96 h EC50 : Algae 37.5 mg/l 48 h EC50 : Daphnia magna (Water flea) 47.4 mg/l Propane(HC-290) 96 h LC50 : Fish 24.11 mg/l Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 42 / 48 72 h EC50 : Algae 7.71 mg/l 48 h EC50 : Daphnia (water flea) 14.22 mg/l n-Butane (HC-600) 96 h LC50 : Fish (unspecified species) > 1,000 mg/l Pentane(HC-601) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 4.26 mg/l 72 h ErC50 : Scenedesmus capricornutum (fresh water algae) 10.7 mg/l 72 h EbC50 : Scenedesmus capricornutum (fresh water algae) 7.51 mg/l 48 h EC50 : Daphnia magna (Water flea) 2.7 mg/l 28 d : NOEC Oncorhynchus mykiss (rainbow trout) 6.165 mg/l 21 d : NOEC Daphnia magna (Water flea) 10.76 mg/l Isobutane (HC-600a) 96 h LC50 : Fish 24.11 mg/l 72 h EC50 : Algae 7.71 mg/l 48 h EC50 : Daphnia (water flea) 14.22 mg/l 2-Methylbutane (HC-601a) 96 h LC50 : Oncorhynchus mykiss (rainbow trout) 4.26 mg/l 72 h ErC50 : Pseudokirchneriella subcapitata (green algae) 25.12 mg/l 72 h ErC50 : Scenedesmus capricornutum (fresh water algae) 10.7 mg/l 72 h EbC50 : Scenedesmus capricornutum (fresh water algae) 7.51 mg/l 48 h EC50 : Daphnia magna (Water flea) 2.3 mg/l 28 d : NOEC Oncorhynchus mykiss (rainbow trout) 7.6 mg/l 21 d : NOEC Daphnia magna (Water flea) 13.29 mg/l Alkylated Benzene Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 43 / 48 96 h LC50 : Lepomis macrochirus (Bluegill sunfish) > 1,000 mg/l Aquatic toxicity is unlikely due to low solubility. 96 h LC50 : Pimephales promelas (fathead minnow) > 1,000 mg/l Aquatic toxicity is unlikely due to low solubility. 96 h : Selenastrum capricornutum (green algae) Aquatic toxicity is unlikely due to low solubility. 48 h EC50 : Daphnia magna (Water flea) OECD Test Guideline 202 Aquatic toxicity is unlikely due to low solubility. Polypropylene Glycol, monobutyl ether 96 h LC50 : Danio rerio (zebra fish) 104 mg/l OECD Test Guideline 203 72 h ErC50 : Pseudokirchneriella subcapitata (green algae) 333 mg/l OECD Test Guideline 201 72 h EbC50 : Pseudokirchneriella subcapitata (green algae) 112 mg/l OECD Test Guideline 201 48 h EC50 : Daphnia magna (Water flea) > 100 mg/l OECD Test Guideline 202 Distillates (Petroleum), clay treated heavy naphthenic; base oil unspecified 96 h LC50 : Pimephales promelas (fathead minnow) > 100 mg/l 48 h EC50 : Daphnia magna (Water flea) > 10,000 mg/l 21 d : NOEC Daphnia magna (Water flea) 1,000 mg/l Distillates (Petroleum), Solvent-Refined Heavy Paraffinic 96 h LC50 : Pimephales promelas (fathead minnow) > 100 mg/l OECD Test Guideline 203 The toxicological data has been taken from products of similar composition. 72 h NOEC : Pseudokirchneriella subcapitata (green algae) > 100 mg/l OECD Test Guideline 201 The toxicological data has been taken from products of similar composition. 48 h EC50 : Daphnia magna (Water flea) > 10,000 mg/l OECD Test Guideline 202 The toxicological data has been taken from products of similar composition. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 44 / 48 21 d : NOEC Daphnia magna (Water flea) 10 mg/l OECD Test Guideline 211 The toxicological data has been taken from products of similar composition. Environmental Fate Chlorodifluoromethane (HCFC-22) Biodegradability : According to the results of tests of biodegradability this product is not readily biodegradable. Difluoromethane (HFC-32) Biodegradability : 5 % OECD Test Guideline 301D Not readily biodegradable. Trifluoromethane (HFC-23) Biodegradability : Not readily biodegradable. Bioaccumulation : Bioconcentration factor (BCF) : 3.2 Bioaccumulation is unlikely. 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) Biodegradability : 24 % Not readily biodegradable. Bioaccumulation : Bioconcentration factor (BCF) : 33 Bioaccumulation is unlikely. 1-Chloro-1,1-difluoroethane (HCFC-142b) Biodegradability : Not readily biodegradable. Bioaccumulation : Bioaccumulation is unlikely. 1,1,1-Trifluoroethane (HFC-143a) Bioaccumulation : Information given is based on data obtained from similar substances. Perfluoropropane (FC-218) Biodegradability : Not biodegradable Not readily biodegradable. Dichlorodifluoromethane (CFC-12) Bioaccumulation : Bioconcentration factor (BCF) : < 10 Bioaccumulation is unlikely. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 45 / 48 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) Bioaccumulation : Bioconcentration factor (BCF) : 11 - 86 Bioaccumulation is unlikely. 1,2-Dichloro-1,1,2,2-tetrafluoroethane (CFC-114) Biodegradability : Not readily biodegradable. Bioaccumulation : Bioaccumulation is unlikely. Perfluoroethane (FC-116) Bioaccumulation : Bioaccumulation is unlikely. n-Butane (HC-600) Biodegradability : 100 % Readily biodegradable Pentane(HC-601) Biodegradability : 71 % Readily biodegradable Bioaccumulation : Bioconcentration factor (BCF) : 171 Bioaccumulation is unlikely. 2-Methylbutane (HC-601a) Biodegradability : 71.43 % Readily biodegradable Bioaccumulation : Bioconcentration factor (BCF) : 171 Bioaccumulation is unlikely. Alkylated Benzene Biodegradability : 60 % OECD Test Guideline 301 Readily biodegradable Bioaccumulation : Bioconcentration factor (BCF) : 35 Bioaccumulation is unlikely. Polypropylene Glycol, monobutyl ether Biodegradability : 79 % OECD Test Guideline 301 Readily biodegradable Bioaccumulation : Bioconcentration factor (BCF) : 3.16 Bioaccumulation is unlikely. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 46 / 48 Distillates (Petroleum), clay treated heavy naphthenic; base oil unspecified Biodegradability : Not readily biodegradable. Distillates (Petroleum), Solvent-Refined Heavy Paraffinic Biodegradability : 31 % OECD Test Guideline 301 Inherently biodegradable. Information given is based on data obtained from similar substances. SECTION 13. DISPOSAL CONSIDERATIONS Waste disposal methods - Product : Comply with applicable Federal, State/Provincial and Local Regulations. Contaminated packaging : Dispose of contents/ container to an approved waste disposal plant. SECTION 14. TRANSPORT INFORMATION DOT UN number : 1078 Proper shipping name : Refrigerant gases, n.o.s. (Fluorinated Hydrocarbons) Class : 2.2 Labelling No. : 2.2 Reportable Quantity : 10 lbs Chlorotrifluoromethane IATA_C UN number : 1078 Proper shipping name : Refrigerant gas, n.o.s. (Fluorinated Hydrocarbons) Class : 2.2 Labelling No. : 2.2 IMDG UN number : 1078 Proper shipping name : REFRIGERANT GAS, N.O.S. (Fluorinated Hydrocarbons) Class : 2.2 Labelling No. : 2.2 The above shipping information applies to all the Used Refrigerants and Refrigerant Blends except Used Refrigerant 11, Used Refrigerant 113, and Used Refrigerant 123. These 3 blends are not classified as Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 47 / 48 dangerous in the meaning of transport regulations. SECTION 15. REGULATORY INFORMATION SARA 313 Regulated Chemical(s) : 2,2-Dichloro-1,1,1-trifluoroethane, 1-Chloro-1,1-difluoroethane , Trichlorofluoromethane , Dichlorodifluoromethane , Chlorotrifluoromethane , Chlorodifluoromethane , 1-Chloro-1,2,2,2-tetrafluoroethane , Cryofluorane PA Right to Know Regulated Chemical(s) : Substances on the Pennsylvania Hazardous Substances List present at a concentration of 1% or more (0.01% for Special Hazardous Substances): Trifluoromethane, 1-Chloro-1,1-difluoroethane, Trichlorofluoromethane, Dichlorodifluoromethane, Chlorotrifluoromethane, Carbon tetrafluoride, Chlorodifluoromethane, Cryofluorane, Difluoromethane, Propane, Butane (<0.1% butadiene), Isobutane (containing ? 0,1 % butadiene (203-450-8)), Isobutane (<0.1% butadiene), Pentane, 2-Methylbutane NJ Right to Know Regulated Chemical(s) : Substances on the New Jersey Workplace Hazardous Substance List present at a concentration of 1% or more (0.1% for substances identified as carcinogens, mutagens or teratogens): Isobutane (<0.1% butadiene), Pentane, 2-Methylbutane, Trifluoromethane, Perfluoroethane, 2,2-Dichloro- 1,1,1-trifluoroethane, 1-Chloro-1,1-difluoroethane, Trichlorofluoromethane, Dichlorodifluoromethane, Chlorotrifluoromethane, Carbon tetrafluoride, Chlorodifluoromethane, 1-Chloro-1,2,2,2-tetrafluoroethane, Cryofluorane, 1,1,1-Trifluoroethane, 1,1-Difluoroethane, Difluoromethane, Octafluoropropane, Propane, Butane (<0.1% butadiene), Isobutane (containing ? 0,1 % butadiene (203-450-8)) CERCLA Reportable Quantity : 1 lbs Based on the percentage composition of this chemical in the product.: Chlorotrifluoromethane California Prop. 65 : WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.Carbon monoxide SECTION 16. OTHER INFORMATION ? DuPont's registered trademark Before use read DuPont's safety information. Safety Data Sheet Used Refrigerants and Refrigerant Blends Version 2.0 Revision Date 05/26/2015 Ref. 130000120029 48 / 48 For further information contact the local DuPont office or DuPont's nominated distributors. Revision Date : 05/26/2015 The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text. Significant change from previous version is denoted with a double bar.